Cooperative Transcription Factor Complexes in Control
نویسندگان
چکیده
منابع مشابه
Identifying transcription factor complexes and their roles
MOTIVATION Eukaryotic gene expression is controlled through molecular logic circuits that combine regulatory signals of many different factors. In particular, complexation of transcription factors (TFs) and other regulatory proteins is a prevailing and highly conserved mechanism of signal integration within critical regulatory pathways and enables us to infer controlled genes as well as the exe...
متن کاملTranscription factor E is a part of transcription elongation complexes.
A homologue of the N-terminal domain of the alpha subunit of the general eukaryotic transcription factor TFE is encoded in the genomes of all sequenced archaea, but the position of archaeal TFE in transcription complexes has not yet been defined. We show here that TFE binds nonspecifically to single-stranded DNA, and photochemical cross-linking revealed TFE binding to a preformed open transcrip...
متن کاملCombining Topological Data to Score Predicted Cooperative Transcription Factor Pairs
INTRODUCTION Combination of different evidences has been used as a means to improve the accuracy of the prediction of different characteristics of genes and networks (von Mering et al., 2002; Troyanskaya et al., 2003; von Mering et al., 2003; Karaoz et al., 2004; Zhang et al., 2004). A number of different approaches have been implemented to this end, ranging from a simple voting function to Bay...
متن کاملCooperative transcription factor associations discovered using regulatory variation.
Regulation of gene expression at the transcriptional level is achieved by complex interactions of transcription factors operating at their target genes. Dissecting the specific combination of factors that bind each target is a significant challenge. Here, we describe in detail the Allele Binding Cooperativity test, which uses variation in transcription factor binding among individuals to discov...
متن کاملAffinity Purification Strategies for Proteomic Analysis of Transcription Factor Complexes
Affinity purification (AP) coupled to mass spectrometry (MS) has been successful in elucidating protein molecular networks of mammalian cells. These approaches have dramatically increased the knowledge of the interconnectivity present among proteins and highlighted biological functions within different protein complexes. Despite significant technical improvements reached in the past years, it i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1231310